A real options approach to growth opportunities and resilience aftermath of the COVID-19 pandemic

PurposeFacing the challenges posed by the pandemic of COVID-19, this paper aims to contribute to the resilience of businesses through the development of a real options approach (ROA) that provides alternatives and opportunities for a decision process under situations when future events and outcomes are unknown and not capable of being known from current information.Design/methodology/approachThis paper involves a stochastic modelling process in generating a set of absolute option values, using available data and scenarios from the COVID-19 pandemic event. The modelling and simulations using ROA suggest how strategic portfolios resolve the growing problem during the endemic to all but in the most isolated societies.FindingsThis study finds the emergent correlation between circuit breakers and lockdowns, which have brought about a "distorted gravity” effect (inverse growth of global businesses and trades). However, "time-to-build” real options (i.e. deferral, expand, switch and compound exchange) start to function in the adaptive-transformative capabilities for growth opportunities of both government and corporate sectors. Significantly, some sectors grow faster than others while the compound exchange remains primarily challenging. Clearly, the government and corporate sectors are entangled, inevitably, the decoherence allows for the former to change uncertainty in the latter;therefore, government sector options change option values in the corporate sector.Originality/valueThe ROA by empirically focusing on both government and corporate sectors demonstrates under conditions of uncertainty how options in decision-making generate opportunities that hitherto have not been recognised and exercised upon by research in the immediate context of the COVID-19 pandemic. Importantly, the ROA provides an insightful concatenation (capability–behaviour approach) that drives resilience.

Feasibility and acceptability pilot of video-based direct observed treatment (vDOT) for supporting antitubercular treatment in South India: a cohort study.

OBJECTIVES: The objective of this study was to assess the feasibility and acceptability of video-based anti-tuberculosis (TB) treatment adherence support in patients with TB (PwTB) in South India. DESIGN: An exploratory cohort. SETTING: Participants were recruited at the TB treatment centre (direct observed treatment short centre) of a tertiary-level teaching facility in Bangalore, Karnataka, South India. PARTICIPANTS: The study enrolled 25 PwTB, with replacement. Adult PwTB who were on drug-sensitive treatment regimens were included, while those who had drug resistant TB were excluded from the study. INTERVENTION: Participants received scheduled adherence reminders and were trained to videorecord themselves swallowing their medication via a mobile application. The application was automated to submit these videos for evaluation. Participants were followed up monthly till treatment completion or withdrawal. OUTCOME MEASURES: Adherence rate and acceptability of video-based directly observed treatment (vDOT). RESULTS: The mean±SD age of the participants was 33±14 years, majority were females (16, 64%), residing in urban areas (24,96%), married (17, 68%) and had access to smart phones (23,92%). A total of 3193 person days of follow-up was completed; of the videos submitted within the first 6 months of enrollment (2501), 94% (2354/2501) were considered 'acceptable' and 16 (64%) participants were optimally adherent (ie, ≥80%). Participant videos improved in quality and a higher proportion met acceptability criteria over time. Twenty-one (84%) participants stated that they found the application easy to learn; 13 (52%) preferred vDOT over DOT. Mixed model logistic regression showed that those who are married are more likely have daily adherence to anti-TB treatment. CONCLUSION: Video-based mobile phone interventions are acceptable to PwTB and the ease of using the application increases with time. To provide patient-centred care, vDOT is a promising option that can be offered to patients for treatment support and adherence monitoring.

The RNA Interference Effector Protein Argonaute 2 Functions as a Restriction Factor Against SARS-CoV-2.

Argonaute 2 (Ago2) is a key component of the RNA interference (RNAi) pathway, a gene-regulatory system that is present in most eukaryotes. Ago2 uses microRNAs (miRNAs) and small interfering RNAs (siRNAs) for targeting to homologous mRNAs which are then degraded or translationally suppressed. In plants and invertebrates, the RNAi pathway has well-described roles in antiviral defense, but its function in limiting viral infections in mammalian cells is less well understood. Here, we examined the role of Ago2 in replication of the betacoronavirus SARS-CoV-2, the etiologic agent of COVID-19. Microscopic analyses of infected cells revealed that a pool of Ago2 closely associates with viral replication sites and gene ablation studies showed that loss of Ago2 resulted in over 1,000-fold increase in peak viral titers. Replication of the alphacoronavirus 229E was also significantly increased in cells lacking Ago2. The antiviral activity of Ago2 was dependent on both its ability to bind small RNAs and its endonuclease function. Interestingly, in cells lacking Dicer, an upstream component of the RNAi pathway, viral replication was the same as in parental cells. This suggests that the antiviral activity of Ago2 is independent of Dicer processed miRNAs. Deep sequencing of infected cells by other groups identified several SARS-CoV-2-derived small RNAs that bind to Ago2. A mutant virus lacking the most abundant ORF7A-derived viral miRNA was found to be significantly less sensitive to Ago2-mediated restriction. This combined with our findings that endonuclease and small RNA-binding functions of Ago2 are required for its antiviral function, suggests that Ago2-small viral RNA complexes target nascent viral RNA produced at replication sites for cleavage. Further studies are required to elucidate the processing mechanism of the viral small RNAs that are used by Ago2 to limit coronavirus replication.

Resilient reverse logistics with blockchain technology in sustainable food supply chain management during COVID‐19

COVID‐19, which is a global problem, affects the all supply chains throughout the world. One of the supply chains most affected by COVID‐19 is food supply chains. Since the sustainable food supply chain processes are complex and vulnerable in terms of product variety, it has been negatively affected by the operational effects of COVID‐19. While the problems experienced in the supply chain processes and raw material constraints caused stops in production, the importance of new business models and production approaches came to the fore. One of the issues of increasing importance is the adoption of reverse logistics activities in sustainable food supply chains and increasing the resilience of food supply chains by integrating blockchain technology into processes. However, adapting blockchain technology to increase the resilience of reverse logistics activities in the food supply chain has advantages as well as risks that need to be considered. Therefore, it is aimed to determine these risks by using fuzzy synthetic evaluation method for eliminating the risks of blockchain adaptation for flexible reverse logistics in food supply chains to increase resiliency. The novelty of this study is that besides discussing about the benefits of BC‐T, it is to identify the risks it can create, to eliminate these risks and to guide the establishment of resilience in reverse logistics activities of SFSCs. According to results, the risks with the highest value among the subrisks are determined as data security risks. Data management risks are calculated as the risk with the highest value.

Guest editorial: Performance measurement in supply chains during disruptions: lessons from the COVID-19 pandemic

[...]it becomes essential to understand the PM aspects in the face of emergency situations such as COVID-19. Since the seminal article by Benita Beamon proposing new performance measures for evaluating supply chain performance, the literature has evolved. [...]the guest editors would also like to thank the authors for their contributions and for choosing our special issue as a relevant platform to communicate their research works. The insights drawn from this SI will provide them with effective guidance to help them design, implement and improve performance measurement systems capable of effectively measuring different supply chain processes and issues during unexpected and disruptive events.Table 1 Articles published in this special issue Article Title Purpose 1 Airline catering supply chain performance during pandemic disruption: a Bayesian network modelling approach This study aims to consider the impact of implementing Bayesian network (BN) modelling to measure SC performance in the airline catering during the pandemic context 2 The role of Industry 4.0 technologies on performance measurement systems of supply chains during global pandemics: an interval-valued intuitionistic hesitant fuzzy approach This study aims to investigate supply chain performance measurement systems (SCPMSs) that are suitable and applicable to evaluate SC performance during unexpected events such as global pandemics. [...]it considers the contribution of Industry 4.0 Disruptive Technologies (IDTs) to implement SCPMSs during such black swan events 3 A systematic literature review on supply chain resilience in SMEs: learnings from COVID-19 pandemic This paper presents the state-of-art literature on supply chain resilience in SMEs in the context of the coronavirus (COVID-19) pandemic and provides a comprehensive view of insights gained and gaps identified and suggests potential areas of future research 4 A proposed circular-SCOR model for supply chain performance measurement in the manufacturing industry during COVID-19 This study aims to determine which supply chain performance criteria come to the fore for the company under consideration to accelerate the transformation into high performance and circularity in supply chains, considering that the ability to analyse supply chain performances and ensure circularity in supply chains has become one of the factors whose importance has increased rapidly with COVID-19 5 How do food supply chain performance measures contribute to sustainable corporate performance during disruptions from the COVID-19 pandemic emergency?

Psychological well-being of young adults during COVID-19 pandemic: Lesson learned and future research agenda.

Psychological and mental well-being has become a topic of concern worldwide after the hit of the COVID-19 pandemic. It has triggered enormous global health care vulnerabilities and resulted in full and partial lockdowns to prevent the new case. This research study provides a comprehensive overview of the published international scientific studies on the effect of COVID-19 on the psychological well-being of young adults. This study aims to review the top-cited authors, documents, journals, productive countries, the most used keywords, and trending themes in this area. Articles related to psychological well-being during the COVID-19 pandemic from January 2020 to December 2022 were extracted from the Scopus database with specified keywords. In total, 482 documents were retrieved as original articles and bibliometric analysis, thematic analysis and content analysis are performed and analyzed. The results show that the United States has contributed the largest publications followed by the United Kingdom and Italy. Through the cluster analysis, it is found that many articles have been published and considered the psychological and mental impact of COVID-19. Young adults from both developed and developing countries are majorly affected by the COVID-19 pandemic. The pandemic prioritizes the importance of global psychological well-being and health care. This study focused on different aspects, such as stress, resilience, and the mental health of young adults. The research findings of this study put forth the urgent need to provide preventive policies and intervention procedures to address the psychological health of young adults and proposed a conceptual framework.

Supply chain management practices, retail outlets attributes and organisational performance: a case of organised food retailers in India

PurposeThe aim of this study is to examine the impact of supply chain management (SCM) practices and retail outlet attributes on the performance of organised food retailers in India during COVID-19 pandemic.Design/methodology/approachAuthors conducted empirical research with SCM practices and retail outlet attributes to evaluate the retailers' performance. The authors present the results from 321 valid responses from the Indian food retailers. The study used structured equation modeling to present the analysis and the results.FindingsThe findings of this study reveal that most of the SCM practices (i.e. information technology, level of information sharing, customer relationship, supplier relationship and goal congruence) have a positive impact on performance except the quality of information sharing. The results show that in the time of the pandemic, the retail outlet attributes (image, service quality and convenience) have no significant relationship with the food retailer's performance while SCM practices are necessary to achieve better performance of the food retailers.Research limitations/implicationsA proactive approach is needed from retailers at the time of pandemic situations to manage the supply chains. The retailers must be extra careful in screening the suppliers for the short and long run. The reason being that in the situation of pandemic, customers might be more demanding and hence, food retailers need to pay special attention to gain growth. It is also required that the policymakers should give importance to the implementation of these SCM practices to be positioned differently.Originality/valueThe research can be valued in terms of its original contribution towards companies in overcoming the disruption caused by COVID-19 to maintain a balance between demand and supply and proposes a completely new theoretical framework. The proposed theoretical model would add value to the existing literature to help the retailers in process of their performance improvement. The study has provided insights for retail organisations, suppliers and government departments to manage their SCs more effectively and efficiently during the pandemic.

Strategic drivers to overcome the impacts of the COVID-19 pandemic: implications for ensuring resilience in supply chains

The recent coronavirus (COVID-19) pandemic has affected the manufacturing industry's entire supply chain system. It is important to investigate the strategic drivers to deal with the impacts of COVID-19 in the manufacturing industry. Accordingly, this study aims to identify the strategic drivers to overcome the impacts of the COVID-19 pandemic and improve the resiliency of the Bangladeshi footwear industry, an emerging economy. The strategic drivers are identified after reviewing research papers, reports, blogs, and discussions on social media platforms. The main drivers and their respective sub-drivers are finalized by discussing with domain experts. To offer strategic plans for building resiliency, it is crucial to know the importance of the main drivers and sub-drivers;therefore, the best–worst method is applied to determine the priority importance of the strategic drivers. The findings indicate that the top five drivers to defeat the impacts of COVID-19 are "high capability of reconfigurability,” "enhance the relationship with suppliers,” "develop health protocols to continue manufacturing,” "government support through incentives, subsidy, tax rebate, etc.,” and "set a policy to stable material supply”. Based on the findings, this study also provides practical implications with proposed research themes for policymakers and operations managers towards mitigating the impacts of the COVID-19 pandemic. The study's contribution is unique and important for the footwear supply chain as the research on COVID-19 in the context of resiliency focusing on the footwear supply chain is non-existent.

Waning of Antibody Response Among Vaccinees who Received Two Doses of Covishield Vaccine.

Introduction: There are limited data available on the long-term presence of SARS-CoV-2-specific binding antibodies and neutralizing antibodies in circulation among the elderly population. This study aims to examine levels of anti-SARS-CoV-2 antibodies in vaccines who have completed at least 6 months since the second vaccine dose. A cross-sectional study was conducted from November 2021 to January 2022 among 199 vaccines aged 60 years and above residing in Belagavi city, who received two doses of the Covishield vaccine. Methods: Antibody response to SARS-COV-2 virus whole cell antigen was measured by a kit COVID KAWACH IgG Micro LISA (J Mitra and Company, India) in 199 participants who had completed at least 6 months after receiving the second dose of Covishield vaccine. The antibody response was measured as a ratio of optical density (OD) in the participant's sample to the mean OD in negative control test by normal (T/N). Independent Kruskal-Wallis test was applied to test the difference between the T/N ratio by months of vaccination since the second dose and by the age group strata. Results: The median T/N values among participants who completed 6, 7, 8, and 9 months since the second vaccine dose were 14.17, 10.46, 7.93, and 5.11, respectively, and this decline in T/N values was statistically significant. Antibody response values showed a decline with increasing age for participants in the age strata 60-69, 70-79, and 80 and above, respectively. Conclusions: A significant decline was observed in antibody response over 9 months supporting the administration of booster dose of vaccine.

Identification of Human Host Substrates of the SARS-CoV-2 Mpro and PLpro Using Subtiligase N-Terminomics.

The recent emergence of SARS-CoV-2 in the human population has caused a global pandemic. The virus encodes two proteases, Mpro and PLpro, that are thought to play key roles in the suppression of host protein synthesis and immune response evasion during infection. To identify the specific host cell substrates of these proteases, active recombinant SARS-CoV-2 Mpro and PLpro were added to A549 and Jurkat human cell lysates, and subtiligase-mediated N-terminomics was used to capture and enrich protease substrate fragments. The precise location of each cleavage site was identified using mass spectrometry. Here, we report the identification of over 200 human host proteins that are potential substrates for SARS-CoV-2 Mpro and PLpro and provide a global mapping of proteolysis for these two viral proteases in vitro. Modulating proteolysis of these substrates will increase our understanding of SARS-CoV-2 pathobiology and COVID-19.

T Cell Response to SARS-CoV-2 Coinfection and Comorbidities.

For the past three years, COVID-19 has become an increasing global health issue. Adaptive immune cells, especially T cells, have been extensively investigated in regard to SARS-CoV-2 infection. However, human health and T cell responses are also impacted by many other pathogens and chronic diseases. We have summarized T cell performance during SARS-CoV-2 coinfection with other viruses, bacteria, and parasites. Furthermore, we distinguished if those altered T cell statuses under coinfection would affect their clinical outcomes, such as symptom severity and hospitalization demand. T cell alteration in diabetes, asthma, and hypertension patients with SARS-CoV-2 infection was also investigated in our study. We have summarized whether changes in T cell response influence the clinical outcome during comorbidities.

Resurgence of Emergency Total Laryngectomy: An Impact of COVID-19 Pandemic.

Laryngeal cancer is one of the most common head and neck cancers in India. Surgery is the preferred modality of treatment in majority of cT4a cases and selective cT3 cases of Carcinoma Larynx. COVID-19 outbreak became a global pandemic and caused significant delays and disruptions in every aspect of cancer care. Similarly, patients of laryngeal cancer presented with advanced disease and significant stridor. In such cases, Emergency total laryngectomy (ETL) proved to be a valid treatment modality in the place of conventional workup and treatment. We present our experience with Emergency laryngectomy during the COVID-19 pandemic and how we overcame its challenges. Supplementary Information: The online version contains supplementary material available at 10.1007/s12070-022-03422-5.

Challenges in Accessing and Delivering Maternal and Child Health Services during the COVID-19 Pandemic: A Cross-Sectional Rapid Survey from Six States of India.

BACKGROUND/OBJECTIVES: Globally, the COVID-19 pandemic and its prevention and control policies have impacted maternal and child health (MCH) services. This study documents the challenges faced by patients in accessing MCH services, and the experiences of health care providers in delivering those services during the COVID-19 outbreak, explicitly focusing on the lockdown period in India. METHODS: A cross-sectional study (rapid survey) was conducted in 18 districts from 6 states of India during March to June, 2020. The sample size included 540 MCH patients, 18 gynaecologists, 18 paediatricians, 18 district immunisation officers and 108 frontline health workers. Bivariate analysis and multivariable analysis were used to assess the association between sociodemographic characteristics, and challenges faced by the patients. RESULTS: More than one-third of patients (n = 212; 39%) reported that accessing MCH services was a challenge during the lockdown period, with major challenges being transportation-related difficulties (n = 99; 46%) unavailability of hospital-based services (n = 54; 23%) and interrupted outreach health services (n = 39; 18.4%). The supply-side challenges mainly included lack of infrastructural preparedness for outbreak situations, and a shortage of human resources. CONCLUSIONS/RECOMMENDATIONS: A holistic approach is required that focuses on both preparedness and response to the outbreak, as well reassignment and reinforcement of health care professionals to continue catering to and maintaining essential MCH services during the pandemic.

Strategies to mitigate inflammation in management of complex congenital heart disease complicated by "multisystem inflammatory syndrome in children".

A 6-month-old boy, a case of Shone's complex, presented in decompensated state was found to have severe mitral stenosis along with multisystem inflammatory syndrome in children (MISC) warranting urgent surgical intervention. Various modalities including cytokine-adsorbing hemofilter were used to target inflammation. Postoperatively, the child recovered from low cardiac output accompanied by decrease in the levels of inflammatory markers, inopressors, and ventilatory requirements. Open heart surgery in itself is a proinflammatory process and is best avoided during the active inflammatory phase of MISC. In the rare and unavoidable circumstance exemplified by this index case, multipronged strategy targeting inflammation as described can be successfully implemented.

Evolution of the COVID-19 Pandemic: An Analysis of the Brunt of the Second and Third Waves on Patients in Western Uttar Pradesh

Background: The recent second wave and the latest third wave of coronavirus disease 2019 (COVID-19) in India caused havoc on health infrastructure. However, there is a scarcity of studies from India and abroad that compare the second and third waves of the COVID-19 pandemic. We aimed to assess the factors like age, sex, and death comparison among diagnostically proven COVID-19 patients of the Meerut district in both waves. Methodology: A total of 297554 samples during the second wave (1st March 2021 to 30th June 2021) and 240655 during the third wave (1st January 2022 to 30th April 2022) were tested for reverse transcription polymerase chain reaction (RT-PCR) in the Department of Microbiology, Lala Lajpat Rai Medical College, using The Indian Council of Medical Research (ICMR) approved RT-PCR testing kits. The data like age, sex, place, follow-ups, etc. were recorded and data were analyzed statistically. Results: The RT-PCR positivity of 8.24% for COVID-19 in the second wave while 5.66% of patients in the third wave have been reported. The proportion of positive cases in children ≤10 years in the second and third wave were quite similar i.e., 3.59% and 3.40% respectively, whereas the proportion of positive cases in adolescents (10-20 years) was significantly higher (12.96%) in the third wave in contrast to the second wave (10.15%), while age group (41-60 years) is significantly less (26.65%) in proportion during the third wave in comparison to the second wave (29.50%). The proportion of positivity in young males has significantly increased in the third wave as compared to the second wave. The mortality also decreased significantly by 1/3rd of the second wave. Conclusion: The third wave showed low overall positivity (5.66%) as compared to the second wave (8.24%), while the brunt on young children was comparable to the second wave which was assumed to be higher. The mortality and hospitalization also decreased significantly in the second wave. Regular surveillance and analysis should continue to combat this pandemic.

Optimization of Biomass Fuel Composition for Rubber Glove Manufacturing in Thailand

The demand for rubber gloves has significantly increased in both medical and non-medical fields due to the spread of the coronavirus in 2019. It is challenging for rubber glove manufacturing industries to balance the production and demand for the product. Additionally, they must determine techniques to decrease the production costs so as to make rubber gloves more economical for consumers. Generally, natural gas, fossil fuels, and renewable energy sources are used worldwide in the manufacturing of rubber gloves. In addition, Thailand uses biomass energy for rubber glove production, but biomass utilization is not economically friendly. This study used different biomasses as fuel in rubber glove production so as to reduce production costs and make the process more environmentally friendly. Wood chip (WC), palm kernel shells (PKS), and oil palm mesocarp fiber (OPMF) biomass were collected from local regions and used in different ratios. The samples of WC, PKS, and OPMF were prepared in four different ratios, namely, 88:12:0, 85:15:0, 85:13:2, and 85:10:5, for efficient biomass utilization. The 85:10:5 (WC: PKS: OPMF) ratio was found to be the optimal ratio as the annual production costs of rubber gloves significantly decreased to USD 1.64 per 1000 units of gloves. Furthermore, this biomass ratio also showed the best boiler efficiency of 74.87%. Therefore, WC, PKS, and OPMF biomass are recommended as fuel for rubber glove industries to make sustainable and economical production processes.

A Study on the Awareness of Academic Practitioners In Cloud Computing Concerning the Institutes offering Technical Education

‘Cloud Computing awareness and adoption is the need of the hour, to meet the current market demands and expectations in terms of quality of education and the competition that market is currently facing, it has become crucial to use technology to the best of its ability to be the bare minimum to land a safe and comfortable jobs that the business atmosphere in and around our country is looking forward to. Either be it a boon or a bane, this is being penetrated to a level that companies like BYJUS, white Hat Jr,, and many more Ed-Tech companies have started programs to preschoolers such as coding, game designing, making them understand the basics of UI/UX aspects. This is very much similar to the 2000-2008 fame waves that competitive exams and colleges like IIT’s and other elite colleges have seen. So it is suggested and insisted to make our working force of the education industry make them well aware of these aspects and prepare them future ready.Objective: To understand the level of awareness on cloud computing among academic practitioners in the Vijayawada and Guntur districts and to determine the level of awareness on the emerging technology. Methodology: A structured questionnaire and survey approach are used to perform the methodological research. Findings: The research identifies that a more collaborative training (train the trainers) is required for the cloud computing technologies among the teaching fraternity. The institutions have incorporated it in their syllabus as professional elective but the awareness and skilling among the practitioners has to be drawn.

Resilient reverse logistics with blockchain technology in sustainable food supply chain management during COVID‐19

COVID-19, which is a global problem, affects the all supply chains throughout the world. One of the supply chains most affected by COVID-19 is food supply chains. Since the sustainable food supply chain processes are complex and vulnerable in terms of product variety, it has been negatively affected by the operational effects of COVID-19. While the problems experienced in the supply chain processes and raw material constraints caused stops in production, the importance of new business models and production approaches came to the fore. One of the issues of increasing importance is the adoption of reverse logistics activities in sustainable food supply chains and increasing the resilience of food supply chains by integrating blockchain technology into processes. However, adapting blockchain technology to increase the resilience of reverse logistics activities in the food supply chain has advantages as well as risks that need to be considered. Therefore, it is aimed to determine these risks by using fuzzy synthetic evaluation method for eliminating the risks of blockchain adaptation for flexible reverse logistics in food supply chains to increase resiliency. The novelty of this study is that besides discussing about the benefits of BC-T, it is to identify the risks it can create, to eliminate these risks and to guide the establishment of resilience in reverse logistics activities of SFSCs. According to results, the risks with the highest value among the subrisks are determined as data security risks. Data management risks are calculated as the risk with the highest value.

Managing disruptions and risks amidst COVID-19 outbreaks: role of blockchain technology in developing resilient food supply chains

This study attempts to present a contribution of Blockchain Technology (BC-T) in managing disruptions, and risk caused by the COVID-19 outbreaks and extending profound support in developing resilient Food Supply Chains (FSCs). The effects of the pandemic can be witnessed on global supply chains in their demand & supply side disruptions and in the changing patterns of consumer buying in the food industry. The assessment of the disruptive factors is required to explore the present issues and promising resilient strategies to impart robustness to the FSCs for mitigating disruptions in the future. An integrated approach of Fuzzy Analytic Hierarchy Process (FAHP) and Weighted Assessment Sum Product Assessment (WASPAS) is employed to assess the factors related to sourcing, lean, workforce, and flexibility, as well as evaluation of the BC-T enabled FSCs resilient strategies that mitigate the effect of disruption during the pandemic. The findings exhibit that ‘Sourcing related’ is the most affecting disruptive factor causing distress in the FSCs and ‘flexibility resilient strategy’ is the most relevant resilient strategy for BC-T enabled FSCs. The BC-T acts as a catalyst in enhancing the flexibility, traceability, and shorter supply chain network structure that may help the FSCs to mitigate risk and disruption in the pandemic situation. The BC-T helps the FSCs to control the demand and supply shocks, and supports the organization with real-time monitoring and sharing information. This study provides insights to the decision-makers, managers, and other stakeholders to take significant decisions during an emergency.

AYURAKSHA, a prophylactic Ayurvedic immunity boosting kit reducing positivity percentage of IgG COVID-19 among frontline Indian Delhi police personnel: A non-randomized controlled intervention trial.

Objective: The world continues to face the COVID-19 crisis, and efforts are underway to integrate traditional medicine interventions for its effective management. The study aimed to determine the efficacy of the "AYURAKSHA" kit in terms of post-interventional percentage of COVID-19 IgG positivity, immunity levels, and quality of life (QoL) against COVID-19. Method: This was a non-randomized controlled, prospective intervention trial, done after the distribution of 80,000 AYURAKSHA kits (constituent of Sanshamani Vati, AYUSH Kadha, and Anu Taila) among Delhi police participants in India. Among 47,827 participants, the trial group (n = 101) was evaluated with the positivity percentage of IgG COVID-19 and Immune Status Questionnaire (ISQ) scores as a primary outcome and the WHO Quality of Life Brief Version (QOL BREF) scores along with hematological parameters as a secondary outcome in comparison to the control group (n = 71). Results: The data showed that the percentage of COVID-19 IgG positivity was significantly lower in the trial group (17.5 %) as compared to the control group (39.4 %, p = 0.003), indicating the lower risk (55.6%) of COVID-19 infection in the trial group. The decreased incidence (5.05%) and reduced mortality percentage (0.44%) of COVID-19 among Delhi police officers during peak times of the pandemic also corroborate our findings. The ISQ score and WHO-QOL BREF tool analysis showed the improved scores in the trial group when compared with the controls. Furthermore, no dysregulated blood profile and no increase in inflammation markers like C-reactive protein, erythrocyte sedimentation rate, Interleukin-6 (IL-6) were observed in the trial group. However, significantly enhanced (p = 0.027) IL-6 levels and random blood sugar levels were found in the control group (p = 0.032), compared to a trial group (p = 0.165) post-intervention. Importantly, the control group showed more significant (p = 0.0001) decline in lymphocyte subsets CD3+ (% change = 21.04), CD4+ (% change = 20.34) and CD8+ (% change = 21.54) levels than in trial group, confirming more severity of COVID-19 infection in the control group. Conclusion: The AYURAKSHA kit is associated with reduced COVID-19 positivity and with a better quality of life among the trial group. Hence, the study encourages in-depth research and future integration of traditional medicines for the prevention of the COVID-19 pandemic. Clinical trial registration: http://ctri.nic.in/, identifier: CTRI/2020/05/025171.